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. 2019 Aug 13;218(10):3455–3471. doi: 10.1083/jcb.201901032

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© 2019 Gong et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 6. — Gulp1 regulates the EphB2/ephrinB1-mediated cell disengagement response. (A–C) Time-lapse images (A and B) and quantification (C) showing expression of dominant-negative Gulp1ΔC inhibits EphB2/ephrinB1-mediated cell disengagement. HeLa cells expressing EphB2 and either GFP or GFP-Gulp1ΔC were cocultured with donor cells expressing ephrinB1ΔC-mCherry. Maximum projection of deconvolved images is shown. Scale bars, 10 µm. Elapsed time shown as min:s. Dashed lines indicate the distance between two contacting cells. Measured distance between donor and responder cells over time for each condition shown as mean ± SEM n = 20 (GFP-Gulp1ΔC) and 13 (GFP) donor–responder pairs from three experiments. ***, P < 0.001; two-way ANOVA.