Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 19;218(10):3171–3187. doi: 10.1083/jcb.201906047

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Sun and Brodsky

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — ER-phagy in yeast and mammals. ER-phagy receptors reside in distinct ER subdomains (yeast, left; mammals, right). ER-phagy receptors concentrate cargo in an ER subdomain via interaction with Atg8 (yeast) or LC3/GABARAP (mammal) in the growing autophagic membrane, the phagophore. ER-phagy substrates are next enclosed in a double-membrane-bound autophagosome, which fuses with the lysosome/vacuole. In yeast, the UPR (black lightning bolt) can give rise to ER whorls, which are nonselectively delivered to the vacuole. In mammals, Sec62 helps reestablish ER homeostasis after UPR induction.