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. 2019 Sep 19;218(10):3436–3454. doi: 10.1083/jcb.201903109

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© 2019 Klapproth et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 10. — A kindlin-3/leupaxin complex regulates paxillin tyrosine phosphorylation and podosome stability. Kindlin-3/leupaxin interaction is independent of integrin binding. However, kindlin-3 targets leupaxin into the podosome adhesion complex. In contrast, paxillin recruitment to podosomes occurs independent of kindlin-3. The recruitment of leupaxin into podosomes enables the tyrosine phosphatase PTP-PEST to dephosphorylate paxillin at Y31 and Y118, resulting in increased podosome lifetime and stability. PH, pleckstrin homology domain.