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. 2019 Aug 26;11(9):433. doi: 10.3390/pharmaceutics11090433

Figure 1.

Figure 1

Study design. Poly(n-butyl cyanoacrylate) microbubbles (PBCA-MB) were synthesized via anionic polymerization of n-butyl-cyanoacrylate (BCA) at pH 2.5. After MB preparation the aqueous suspension of MB were stored at 4, 25, and 37 °C and the change in their physical properties were monitored over the duration of 20 weeks with techniques like Scanning electron microscope (SEM), stimulated emission depletion (STED) microscopy, and ultrasound (US). The aqueous MB suspension was also lyophilized. Furthermore, the lyophilizates were analyzed with the same techniques.