Table III.

Summaries for the function of 10 hub genes.

No.	Gene symbol	Full name	Function
1	CDK1	Cyclin dependent kinase 1	Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins.
2	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	Implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
3	NDC80	NDC80, kinetochore complex component	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
4	NCAPG	Non-SMC condensin I complex subunit G	Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromo somes.
5	BUB1	BUB1 mitotic checkpoint	Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: It is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment.
6	CCNB1	Cyclin B1	Essential for the control of the cell cycle at the G2/M (mitosis) transition.
7	TOP2A	Topoisomerase	Diseases associated with TOP2A include Female Breast Cancer and
		(DNA) II alpha	Malignant Peripheral Nerve Sheath Tumor. Among its related pathways are Cell Cycle, Mitotic and SUMOylation.
8	DLGAP5	DLG associated protein 5	Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin- proteasome pathway.
9	ASPM	Abnormal spindle microtubule assembly	Involved in mitotic spindle regulation and coordination of mitotic. processes
10	MELK	Maternal embryonic leucine zipper kinase	Diseases associated with MELK include Uterine Corpus Endometrial Carcinoma. Among its related pathways are Neuroscience.