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. 2019 Sep 20;18(5):5408–5416. doi: 10.3892/ol.2019.10902

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Copyright: © Ji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Talin1 expression is upregulated in colorectal cancer and it increases proliferation of HCT116 cells. (A) IHC demonstrating the distribution of talin1 in tumor (+++) and normal (+) tissues. Magnification, ×400. (B) Quantification of talin1 distribution in the IHC assays from at least 30 patients. (C) Western blotting results of talin1 protein expression in talin1-knockdown HCT116 cell lines and HCT116 cells transfected with the shRNA control. (D) Talin1 mRNA levels in talin1-knockdown HCT116 cell lines and HCT116 cells transfected with the shRNA control (n=5). (E) Talin1 protein levels in talin1-knockdown HCT116 cell lines and HCT116 cells transfected with the shRNA control (n=3). (F) Knockdown of endogenous talin1 inhibited the proliferation of HCT116 cells. Data are expressed as the mean ± SEM. **P<0.01 and ***P<0.001 vs. control. IHC, immunohistochemistry; shRNA, short hairpin RNA.