Table I.
Full name, abbreviation and function of 17 hub genes with node degree ≥10.
| No. | Gene symbol | Full name | Function |
|---|---|---|---|
| 1 | TYMS | Thymidylate synthetase | DNA synthesis, DNA repair and proliferation of cancer cells. |
| 2 | CCNB2 | Cyclin B2 | Correlated with invasion, metastasis and poor prognosis of various cancer types. |
| 3 | RFC4 | Replication factor C subunit 4 | Associated with poorly differentiated and advanced |
| Tumor-Node-Metastasis stage in multiple cancer types. | |||
| 4 | BIRC5 | Baculoviral IAP repeat containing 5 | Plays a key role in proliferation, apoptosis and angiogenesis of LUSC. |
| 5 | GAPDH | Glyceraldehyde-3-Phosphate dehydrogenase | Elevated GAPDH significantly promotes cell proliferation and migration in LUSC. |
| 6 | CKS1B | CDC28 protein kinase regulatory subunit 1B | Attributes to prognosis, chemoresistance and chemosensitivity in cancer. |
| 7 | MCM6 | Minichromosome maintenance complex component 6 | Initiation of DNA replication and a marker for proliferating cells. |
| 8 | EZH2 | Enhancer of Zeste 2 polycomb repressive complex 2 subunit | Invasion, cell proliferation and adverse prognosis in LUSC. |
| 9 | PTTG1 | Pituitary tumor-transforming 1 | Carcinogenesis, migration, invasion and prognosis. |
| 10 | CDK4 | Cyclin dependent kinase 4 | Regulates cell cycle positively, overexpressed and gene amplified in LUSC. |
| 11 | TPX2 | TPX2, microtubule nucleation factor | Overexpression associated with differentiation grade, stage and metastasis of LUSC. |
| 12 | PRC1 | Protein regulator of cytokinesis 1 | Promotes progression and migration in LUSC. |
| 13 | CKS2 | CDC28 protein kinase regulatory subunit 2 | Inhibit DNA damage response and contribute to tumor cell proliferation in breast cancer |
| 14 | CDC45 | Cell division cycle 45 | Regulator of cell proliferation and associated with S-phase DNA damage. |
| 15 | KPNA2 | Karyopherin subunit alpha 2 | Attributed to cancer cell proliferation and metastasis. |
| 16 | NCAPG | Non-SMC condensin I complex subunit G | Associated with cell cycle, apoptosis and migration in human hepatocellular carcinoma. |
| 17 | UBE2S | Ubiquitin conjugating enzyme E2 S | Involved in the malignant characteristics, mitosis and survival of various types of cancer cells. |