Table I.

Functions of the 10 hub genes.

Gene symbol	Full name	Function
IL-6	Interleukin 6	Encodes a cytokine that functions in inflammation and the maturation of B cells
MYC	MYC proto-oncogene	Proto-oncogene that encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation
SST	Somatostatin	Inhibits the release of numerous secondary hormones
CXCL12	CXC motif chemokine ligand 12	Plays a role in a number of cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis and tumor growth and metastasis
NPY	Neuropeptide Y	Influences several physiological processes, including cortical excitability, stress response, food intake, circadian rhythms and cardiovascular function
LPAR1	Lysophosphatidic acid receptor 1	Encodes the lysophosphatidic acid receptor, mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, chemotaxis, and tumor cell invasion.
PLA2G1B	Phospholipase A2 group 1B	Encodes a secreted member of the phospholipase A2 class of enzymes. The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response.
CPB1	Carboxypeptidase B1	Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants.
PNLIP	Pancreatic lipase	Encodes an enzyme involved in the digestion of dietary fats
KLF4	Kruppel like Factor 4	The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53.