Table III.
Univariate and multivariate analysis of prognostic factors for overall survival in gastric cancer.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | P-value | 95% CI | HR | P-value | 95% CI | |
| PSMA7 expression | ||||||
| High vs. low or no | 1.005 | <0.001 | 1.003–1.007 | 0.995 | 0.001 | 0.993–0.998 |
| Age, years | ||||||
| ≤60 vs. >60 | 3.135 | <0.001 | 2.209–4.450 | |||
| Sex | ||||||
| Male vs. female | 1.109 | 0.903 | 0.747–1.390 | |||
| Histological type, tubular vs. mucinous vs. mixed (tubular and mucinous) vs. signet ring cell vs. othersa | 1.015 | 0.802 | 0.901–1.145 | |||
| Differentiation, well vs. moderate vs. poor vs. othersb | 1.393 | 0.002 | 1.131–1.715 | |||
| Tumor invasion, Tis vs. T1 vs. T2 vs. T3 vs. T4 | 2.059 | <0.001 | 1.714–2.411 | |||
| Lymph node metastasis, N0 vs. N1 vs. N2 vs. N3 | 1.773 | <0.001 | 1.576–1.995 | 1.592 | <0.001 | 1.305–1.941 |
| Distant metastasis, M0 vs. M1 | 3.316 | <0.001 | 2.063–5.330 | |||
| TNM stage, 0 vs. I vs. II vs. III vs. IV | 2.059 | <0.001 | 1.764–2.402 | 1.592 | <0.001 | 1.219–2.709 |
| CEA, ≤5 vs. >5 | 1.151 | 0.053 | 0.998–1.328 | |||
| CA199, ≤37 vs. >37 | 1.133 | 0.081 | 0.985–1.303 | |||
a
Papillary adenocarcinoma, 9 cases; adeno squamous carcinoma, 3 cases; squamous cell carcinoma, 4 cases; neuroendocrine carcinoma, 2 cases.
b
Including undifferentiated and unknown. CA199, carbohydrate antigen 19-9; CEA, carcinoembrynoc antigen; CI, confidence interval; HR, hazard ratio; M0, metastasis-negative; M1, metastasis-positive; N0, node-negative; N1, 1–2 nodes; N2, 3–6 nodes; N3, >6 nodes; PMSA7, proteomic subunit α7; T1, lamina propria; T2, muscularis propria; T3, subserosa; T4, adjacent structures; Tis, carcinoma in situ; TNM, Tumor-Node-Metastasis.