Table I.
Targets of microRNA-146a.
| Target gene | Type of cell | Functions | (Refs.) |
|---|---|---|---|
| EGFR | Breast, pancreatic and gastric cancer cells | Cell proliferation, invasion and metastasis | (7–9) |
| TRAF6, IRAK1 | LPS-stimulated monocytes, Th17 cells, human stellate cells | Innate immunity response, T cell-mediated autoimmunity, anti-fibrotic effect | (12,43,59) |
| IL-8, CCL-5 | Lung epithelial alveolar | Acute inflammatory responses | (13) |
| IRAK2 | VSV-infected macrophages | Innate immunity response | (14) |
| IL-6 | Pulmonary macrophages | Paraquat poison | (15) |
| KDM2B | HPV16-positive keratinocytes | Cell proliferation, migration | (16) |
| COX-2, FLAP | Lung adenocarcinoma cells | Cell proliferation, migration | (17,18) |
| FADD | T lymphocytes | Anti-apoptotic effect | (34) |
| Stat1 | Treg cells, Tfh cells, NK/T cells | Immune homeostasis, limiting the number of Tfh cells, NK/T cell function | (39,54,55) |
| Itch | Th2 cells | Th1/Th17 skewing | (41) |
| ICOS | Tfh cells | Limiting the number of GC B cells | (44) |
| Numb | MZ B cells | MZ B cell differentiation | (49) |
| CFH | HBV-infected hepatocytes | Hepatitis | (51) |
| HNF1α | Hepatocytes | Hepatitis, hepatic fibrosis | (57) |
| BRCA1 | HUVECS | Microvascular invasion | (62) |
| HAb18G | Hepatocytes | Cell migration, metastasis | (63) |
EGFR, epidermal growth factor receptor; TRAF6, TNF receptor-associated factor 6; RAK1, interleukin IL-1 receptor associated kinase 1; IRAK2, IL-1 receptor associated kinase 2; COX-2, cyclooxygenases; FLAP, 5-lipoxygenase activating protein; CFH, complement factor H; HNF1α, hepatocyte nuclear factor 1α; LPS, Lipopolysaccharide; Th cells, T helper cells; HPV, human papillomavirus; Treg cells, regulatory T cells; Tfh cells, T follicular helper cells; MZ B cells, marginal zone B cells; HUVECs, human umbilical vein endothelial cells; VSV, vesicular stomatitis virus; GC, gastric cancer; NK, natural killer.