. 2019 Oct 1;12:8033–8046. doi: 10.2147/OTT.S220730

Table 2.

Studies Comparing Photon Versus Proton Involved Node/site Radiotherapy In Lymphoma

		No.	Clinical Scenario	Delivery Technique					Organs At Risk							Other
		No.	Clinical Scenario	FB			DIBH									Other
Localization	3DCRT	mRT	PT	IMRT	PT	Heart	Lung	Breasts	Thyroid	Esophagus	Body
Clinical stage I–II
Chera⁵⁷		9	Primary	Upper mediastinal	274C	x	x			x	x	x	x
Horn⁵⁸		14	Primary	Mediastinal	x	Tomo	PS			x	x	x			x
Jørgensen⁵²		46	Primary	Supra-diaphragmatic	x	VMAT	PBS							x
Maraldo⁵³		27	Primary	Mediastinal	x	VMAT	PBS			x	x	x
Maraldo⁵⁴		46	Primary	Supra-diaphragmatic	x	VMAT	PBS									Carotid arteries
Maraldo⁵⁵		37	Primary	Cervical involvement	x	VMAT	PBS						x			Neck, thyroid, pharynx, larynx, salivary & parotid glands
Rechner⁴⁴		22	Primary	Mediastinal		IMRT	PBS	IMRT	PBS	x	x	x
Clinical stage I–IV
Baues⁴⁵		21	Primary	Mediastinal				VMAT	PBS	x	x	x
Hoppe⁴⁹		20	Primary and R/R	Mediastinal	x	IMRT	PS			x	x	x	x	x	x
Hoppe⁵⁰		13	Primary and R/R	Mediastinal	x	IMRT	PS									Cardiac substructures
Knausl⁴⁸		10	Primary	N/A	x	IMRT	PS			x	x	x	x			Bones
König²⁶		20	Primary	Mediastinal		Tomo	PBS			x	x	x		x		Spinal cord
Li⁴⁷		10	R/R	Upper mediastinal	x					x	x			x		Coronary arteries
Sachsman⁵¹		12	Primary and R/R	Sub-/infra-diaphragmatic	X	IMRT	PS									Stomach, liver, pancreas, bowel, kidneys
Stage N/A
Everett⁴⁶		21	?	Lower mediastinal		Butterfly IMRT	PS	Butterfly IMRT	PS	x	x	x	x	x		LADCA
Zeng⁵⁶		10	At least one R/R	Mediastinal	x	IMRT	PBS			x	x	x				Spinal cord

Abbreviations: 3DCRT, 3-dimensional conformal radiotherapy; DIBH, deep inspiration breath-hold; FB, free breathing; IMRT, intensity modulated radiotherapy; LADCA, left artery descending coronary artery; mRT, modern radiotherapy; N/A, not available; PBS, pencil beam scanning proton therapy; PS, passive scatter proton therapy; PT, proton therapy; R/R, relapsed/refractory disease; Tomo, helical tomotherapy; VMAT, volumetric arc therapy.