Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A simplified scheme illustrating metabolic fates of tryptophan and potential consequences of imbalance in its turnover. Kynurenine pathway is the major route for tryptophan metabolism in most mammalian tissues (the metabolites within the scope of this paper are inside a blue box). KYNA is an agonist of aryl hydrocarbon receptor (AhR) and functions as an ROS scavenger and suppresses inflammatory response. A shift toward 3-HK and NAD+ production enhances inflammation.
