Table II.
Association between mean Cq values and histologic groups.
| Housekeeping genes | HFS | CIN 1 | CIN 2 | CIN 3 | CC | P-value |
|---|---|---|---|---|---|---|
| U6 | 27.76±0.48 | 26.47±1.38 | 22.44±12.71 | 24.40±1.77 | 25.41±1.97 | 0.060 |
| miR-16 | 11.19±17.49 | 7.35±15.51 | – | 21.16±19.34 | 34.94±1.94 | 0.045a |
| RNU-44 | 30.03±3.49 | 28.78±2.06 | 31.25±2.41 | 26.74±1.47 | 20.60±11.60 | 0.004a |
| RNU-47 | 34.16±2.85 | 32.68±2.85 | 27.78±15.58 | 31.09±1.62 | 30.94±1.80 | 0.064 |
| RNU-48 | 29.45±2.72 | 28.51±2.14 | 31.94±2.08 | 27.64±1.77 | 27.27±2.30 | 0.022a |
| RNU-49 | 30.67±2.73 | 29.77±2.07 | 23.84±13.34 | 28.51±1.03 | 28.08±0.95 | 0.128 |
-, no amplification.
a
P<0.05. CC, cervical cancer; CIN, cervical intraepithelial neoplasia; Cq, cycle quantification; HFS, healthy female subjects.