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. 2019 Sep 12;18(5):5332–5340. doi: 10.3892/ol.2019.10860

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Copyright: © Pan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — SNX3 may reverse EMT of CRC cells by regulating β-catenin. (A) Protein expression levels of β-catenin were determined by western blotting. (B) β-catenin expression was semi-quantified. (C) Following transfection with sh-SNX3, the expression levels of β-catenin were detected by western blotting. (D) Protein expression levels of β-catenin and EMT-associated proteins in NC-HT29, shSNX3-HT29 and shSNX3-HT29-si-β-catenin cells were analyzed by western blotting with GAPDH as the loading control. (E) Transwell assays were performed to determine the migratory and invasive abilities of NC-HT29, shSNX3-HT29 and shSNX3-HT29-si-β-catenin cells; scale bar, 200 µm. *P<0.05; **P<0.01; ***P<0.001. EMT, epithelial-mesenchymal transition; NC, negative control; sh, small hairpin RNA; si, small interfering RNA; SNX3, sorting nexin 3.