Figure 6.

SNX3 inhibits the metastasis of colorectal cancer cells in a xenograft mouse model. (A) Nude mice were intravenously injected with NC-HCT116 or SNX3-HCT116 cells. The average body weight of nude mice was measured. (B) Representative images of the lungs dissected from nude mice are presented (black arrows show the metastatic nodes). Upper scale bars, 500 µm. Lower scale bars, 200 µm. (C) Number of metastatic nodes was measured. (D) Hematoxylin and eosin staining of lung tissue images of representative mice from the different experimental groups 8 weeks after injection. *P<0.05; **P<0.01. NC, negative control; SNX3, sorting nexin 3.