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. 2019 Oct 1;7:212. doi: 10.3389/fcell.2019.00212

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Copyright © 2019 Yan, Chen, Wang, Hu, Huang, Lu and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CCL19 and CCR7 mediate virus antigen uptake and immunocyte activation and differentiation. DC, B and T lymphopoiesis are characterized by sequential changes in migration properties. Surface receptor and Ig expression occurs during T lymphopoiesis in bone marrow and the thymus during immune response initiation and the generation of effector T cells for participation in active defense at virus entry sites in peripheral tissues, including blood, lymph, mucosal venules and MALT; thereby, inflammation and the establishment of memory cells for immune surveillance occur. α4β7, integrin α4β7; LFA-1, lymphocyte function-associated antigen-1; ASC, antibody-secreting cell; MALT, mucosal-associated lymphoid tissue. Other mucosal compartments: colon, alveolus, mammary and salivary glands, genital mucosa.