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. 2019 Sep 18;18(5):3767–3774. doi: 10.3892/etm.2019.8018

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Copyright: © Dong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — β-asarone increases CREB, BDNF and Trk-B levels in the hippocampus of chronic unpredictable mild stress-treated rats. (A) Western blot analysis to examine CREB, BDNF and Trk-B protein levels. (B) CREB, (C) BDNF and (D) Trk-B mRNA levels in different groups were detected by reverse transcription-quantitative polymerase chain reaction. Data are expressed as the mean ± standard deviation. **P<0.01 vs. control group; #P<0.05 and ##P<0.01, vs. model group. β-asarone1/2/3, depression model rats treated with 12.5, 25 or 50 mg/kg β-asarone, respectively; FLU, fluoxetine-treated depression rats; CREB, cAMP response element binding protein; BDNF, brain-derived neurotrophic factor; Trk-B, tropomyosin receptor kinase B.