Table 1.
Clinical and laboratory characteristics of the study group (N = 209)
| Number of concomitant medications | |||
|---|---|---|---|
| 0 n = 69 | 1-5 n = 107 | ≥ 5 n = 33 | |
| Age, years (±SD) | 48.7 (13.1) | 53.2 (12.0) | 58.0 (8.7) |
| Gender | |||
| Male, n (%) | 33 (47.8) | 39 (36.4) | 21 (63.4) |
| BMI, kg/m2 (±SD) | 25.2 (3.9) | 26.9 (3.9) | 27.1 (3.7) |
| Treatment history, n (%) | |||
| Naïve | 18 (26.1) | 23 (21.5) | 3 (9.1) |
| Partial responder | 8 (11.6) | 8 (7.5) | 1 (3.0) |
| Relapser | 11 (15.9) | 20 (18.7) | 6 (18.2) |
| Null-responder | 26 (37.7) | 41 (38.1) | 17 (51.5) |
| Discontinued | 3 (4.3) | 8 (7.5) | 1 (3.0) |
| Unknown | 3 (4.3) | 7 (6.5) | 5 (15.2) |
| Fibrosis stage, n (%) | |||
| F0 | 2 (2.9) | 0 (0.0) | 2 (6.1) |
| F1 | 8 (11.6) | 8 (7.5) | 5 (15.2) |
| F2 | 11 (15.9) | 10 (9.3) | 8 (24.2) |
| F3 | 8 (11.6) | 20 (18.7) | 4 (12.1) |
| F4 | 40 (58.0) | 67 (62.6) | 12 (36.4) |
| HCV genotype, n (%) | |||
| 1a | 9 (13.0) | 3 (2.8) | 1 (3.0) |
| 1b | 52 (75.4) | 92 (86.0) | 32 (97.0) |
| 1 (subgenotyping not available) | 3 (4.3) | 4 (3.7) | 0 (0.0) |
| 4 | 4 (5.8) | 5 (4.7) | 0 (0.0) |
| HCV RNA level, × 106 IU/ml (SD) | 1.3 (2.0) | 1.3 (1.8) | 2.2 (2.7) |
| Bilirubin, mg/dl (SD) | 2.6 (12.1) | 4.0 (16.57) | 1.2 (0.84) |
| ALT, IU/ml (SD) | 106.5 (91.3) | 105.6 (75.8) | 79.6 (44.9) |
| INR (SD) | 1.1 (0.2) | 1.1 (0.2) | 1.1 (0.2) |
| Hemoglobin, g/dl (SD) | 14.5 (1.6) | 14.7 (1.5) | 13.7 (1.8) |
| PLT, × 103 cells/μl (SD) | 154.8 (83.3) | 123.4 (62.2) | 148.8 (72.0) |
| Albumin, g/dl (SD) | 5.5 (11.9) | 4.9 (9.5) | 4.0 (0.7) |
| Alpha fetoprotein, μg/l (SD) | 14.5 (26.7) | 15.8 (28.3) | 39.9 (119.8) |
| Creatinine, mg/dl (SD) | 0.8 (0.2) | 0.8 (0.2) | 1.0 (0.4) |
| Child-Pugh score, points (SD) | 5.2 (0.6) | 5.4 (0.8) | 5.6 (1.1) |
| MELD score, points (SD) | 8.0 (2.6) | 8.3 (2.7) | 8.7 (3.2) |
ALT – alanine transaminase, BMI – body mass index, HCV RNA – HCV ribonucleic acid, INR – international normalized ratio, MELD – Model for End-Stage Liver Disease, PLT – platelet count, SD – standard deviation