Figure 4.

Latent environments in GTEx and CAD risk. (A) Enrichment of GTEx eQTLs in SNPs within response factor footprints for each treatment. (B) Enrichment of coronary artery disease risk loci in SNPs within response factor footprints for each treatment. (C) For the genes shown in (D), number of concordant (treatment changes gene expression in the same direction as TWAS risk) and discordant (vice versa) gene/treatment pairs. (D) Comparison of logFC of gene expression vs. CAD TWAS z-score. A positive logFC indicates that the treatment increases gene expression. A positive TWAS value indicates that increased expression of the gene is associated with CAD risk.