Table 1. Major players in TOR signaling.
| Gene | Sequence name | Mammalian homolog | References | ||
|---|---|---|---|---|---|
| Complex components | |||||
| let-363 | B0261.2 | TOR | Long et al. (2002) | ||
| daf-15 | C10C5.6 | RAPTOR | Hara et al. (2002) | ||
| rict-1 | F29C12.3 | RICTOR | Jones et al. (2009), Soukas et al. (2009) | ||
| mlst-8 | C10H11.8 | mLST8 | Jones et al. (2009) | ||
| sinh-1 | Y57A10A.20 | mSIN1 | Soukas et al. (2009) | ||
| No homolog identified | DEPTOR | ||||
| No homolog identified | PRAS40 | ||||
| Interactors | |||||
| raga-1 | T24F1.1 | RAGA/RAGB | Schreiber et al. (2010) | ||
| ragc-1 | Y24F12A.2 | RAGC/RAGD | Fukuyama et al. (2012), Robida-Stubbs et al. (2012) | ||
| rheb-1 | F54C8.5 | RHEB | Honjoh et al. (2009) | ||
| No homolog identified | LAMTOR1 | ||||
| lmtr-2 | Y97E10AR.7 | LAMTOR2 | Kim et al. (2018) | ||
| lmtr-3 | C06H2.6 | LAMTOR3 | Shaye and Greenwald (2011), Kim and Guan (2019) | ||
| T08A11.1 | T08A11.1 | DEPDC5 | Kim et al. (2018) | ||
| nprl-2 | F49E8.1 | NPRL2 | Zhu et al. (2013) | ||
| nprl-3 | F35H10.7 | NPRL3 | Zhu et al. (2013) | ||
| F39C12.1 | F39C12.1 | MIOS | |||
| Y32H12A.8 | Y32H12A.8 | WDR24 | Kim et al. (2018) | ||
| No homolog identified | WDR59 | ||||
| npp-18 | Y43F4B.4 | SEH1L | Kim et al. (2018) | ||
| npp-20 | Y77E11A.13 | SEC13 | Galy et al. (2003) | ||
| F13H10.3 | F13H10.3 | SLC38A9 | Kim et al. (2018) | ||
| sesn-1 | Y74C9A.5 | SESN2 | Yang et al. (2013) | ||
| No homolog identified | CASTOR1 | ||||
| No homolog identified | CASTOR2 | ||||
| F54B3.1 | F54B3.1 | SZT2 | Kim et al. (2018) | ||
| No homolog identified | KPTN | ||||
| No homolog identified | ITFG2 | ||||
| No homolog identified | C12orf66 | ||||
| Substrates | |||||
| pgl-1 | ZK381.4 | none | Zhang et al. (2018) | ||
| pgl-3 | C18G1.4 | none | Zhang et al. (2018) | ||
| rsks-1 | Y47D3A.16 | S6K | Long et al. (2002) | ||
| ifet-1a | F56F3.1 | 4E-BP | Li et al. (2009), Nukazuka et al. (2011) | ||
| atg-13 | D2007.5 | ATG13 | Tian et al. (2010) | ||
| sgk-1 | W10G6.2 | SGK1 | Hertweck et al. (2004) | ||
| pkc-2 | E01H11.1 | PKC(βδζ) | Islas-Trejo et al. (1997) | ||
| akt-1 | C12D8.10 | AKT | Paradis and Ruvkun (1998) | ||
| akt-2 | F28H6.1 | AKT | Paradis and Ruvkun (1998) | ||
| Regulators | |||||
| aak-1 | PAR2.3 | PRKAA(1,2),AMPK | Fukuyama et al. (2012) | ||
| aak-2 | T01C8.1 | PRKAA(1,2),AMPK | Fukuyama et al. (2012) | ||
| daf-18 | T07A9.6 | PTEN | Fukuyama et al. (2012) | ||
| daf-16 | R13H8.1 | FoxO | Jia et al. (2004) | ||
| No homolog identified | TSC1 | ||||
| No homolog identified | TSC2 | ||||
This table includes the C. elegans homologs of genes that encode proteins identified as components, interactors, substrates, or regulators of mTORC1 or mTORC2. They are organized by their putative roles in TOR signaling, although many need further characterization to determine function. “No homolog identified” means no apparent homolog based on ortholog prediction programs (Kim et al. 2018), but it is possible that there is a functional ortholog that is too diverged to identify in this manner. The references listed correspond to the related C. elegans studies. TOR, Target of Rapamycin; TORC, TOR Complex.
a
ifet-1 has also been known as spn-2.