Figure 2.
The sqv-3 and svh-11 genes are required for axon regeneration. (A) Representative D-type motor neurons in wild-type, sqv-3, and svh-11 mutant animals 24 hr after laser surgery. In wild-type animals, a severed axon has regenerated a growth cone (arrow). In mutants, the proximal ends of axons failed to regenerate (arrowheads). Bar, 10 μm. (B and C) Percentages of axons that initiated regeneration 24 hr after laser surgery. The numbers (n) of axons examined are shown. Error bars indicate 95% confidence intervals. * P < 0.05, ** P < 0.01, *** P < 0.001 as determined by Fisher’s exact test. NS, not significant.
