Table 2.

Literature review on platelet function studies in ASD patients

Functional platelet test	Number of ASD samples	Agonists	Study outcome	References
Aggregation	14	ADP, collagen	Reduced platelet aggregation with both agonists but did not reach significance due to low sample size	Safai‐Kutti et al73
Aggregation	7	ADP and 5‐HT	Reduced 5‐HT amplified aggregation indicating a defect in platelet 5‐HT2 receptor complex	McBridge et al102
Aggregation	17	ADP	Marginally significant reduction in aggregation in ASD patients with normal platelet 5‐HT levels indicating that the platelet functional defect could be independent of the serotonergic system	Hranilović et al74
ATP secretion	159	ADP, collagen	Reduced stimulated release of ATP from platelets of ASD patients and first‐degree relatives indicating potentially heritable dense granule secretion defect	Bijl et al59

Abbreviations: 5‐HT, 5‐hydroxytryptamine; ASD, autism spectrum disorder.