Table 5. Significant associations between SNPs and NAFLD phenotypes in a covariate adjusted linear regression analysis.
Trait | Gene | SNP | Risk allele | β-coefficient | STAT | P |
BMI | KLB | rs7670903 | A | 0.40 | 3.49 | <0.001 |
ALT | KLB | rs7674434 | G | 2.59 | 2.17 | 0.030 |
rs12152703 | T | 2.47 | 2.04 | 0.041 | ||
γ-GT | KLB | rs7674434 | G | 2.77 | 2.15 | 0.032 |
rs12152703 | T | 2.94 | 2.26 | 0.024 | ||
rs7670903 | A | 1.78 | 2.12 | 0.034 | ||
AST/ALT | KLB | rs7674434 | G | 0.06 | 2.26 | 0.024 |
rs12152703 | T | 0.05 | 2.47 | 0.013 | ||
FGF21 | FGF21 | rs499765 | G | 19.35 | 1.97 | 0.049 |
β-coefficient: estimated quantitative effect of each SNP minor allele copy on a phenotype of NAFLD, STAT: T statistic, P: level of statistical significance of the covariate adjusted linear regression analysis.