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. 2019 Sep 16;11(18):7473–7491. doi: 10.18632/aging.102254

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Copyright © 2019 Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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HnRNPR promoted cancer aggressiveness by binding CENPF mRNA. (A) GSEA analysis indicated that high hnRNPR expression positively correlated with three metastasis signatures. (B) Venn graph indicated that CENPA, CENPN, RFC4, BUB1, BIRC5, AURKA, CENPF, DLGAP5, ECT2, and CCNB2 were overlapped in the three groups. (C) The expression of CENPF was positively correlated with that of hnRNPR. (D) The CENPF expression in gastric tumors was significantly higher than that in normal tissues in TAGC-STAD database. (E) RIP-PCR revealed that CENPF RNA is enriched in the hnRNPR group compared to the control. (F) Two (HGC-27 and SGC-7901) cell lines control and hnRNPR cells were transfected with shRNA control or shRNA against CENPF for Immuno-blotting. (G) Migration and (H) invasion assays showed that inhibition of CENPF rescued the aggressiveness induced by hnRNPR in SGC7901 and HGC-27 cell lines. Data were from three independent experiments performed in triplicate. P values were calculated with two-tailed unpaired Student’s t test. The expression correlation was determined with Pearson’s correlation analysis. *, P<0.05, **, P<0.01.