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. 2019 Oct;71(4):571–595. doi: 10.1124/pr.119.017863

TABLE 3.

Recent data on allosteric effect of Na⁺

Receptor	Allosteric Effect [Na⁺]	Estimate of Na⁺ Affinity	PDB ID (Na⁺ in Structure)	Reference
DRD4	Agonist NAM, reduce basal activity	K_B = 98 mM	5WIV (Na+)	Wang et al. (2017)
DRD2	Agonist NAM, control of other allosteric ligands	K_B = 123.1 mM	6CM4	Wang et al. (2017), Draper-Joyce et al. (2018)
DRD3	Agonist NAM	K_B = 76 mM	3PBL	Wang et al. (2017)
MOR	Agonist NAM, control of other allosteric ligands	K_B = 7.3 mM	4DKL	Wang et al. (2017), Livingston et al. (2018)
DOR	Agonist NAM, control of other allosteric ligands	K_B = 24.3 mM	4N6H (Na⁺)	Wang et al. (2017)
A_2AR	Agonist NAM	K_B = 32.4 mM	4EIY (Na⁺)	Wang et al. (2017)
CLTR1	Receptor thermostability	EC₅₀ = 39 mM	6RZ4, 6RZ5 (Na⁺)	Luginina et al. (2019)
BLT1	Agonist NAM	EC₅₀ < 200 mM^a	5X33 (Na⁺ site blocked by ligand)	Hori et al. (2018)
V1b	Agonist NAM, required for IP3 signaling	EC₅₀ < 50 mM^a	n/a	Koshimizu et al. (2016)
OXTR	Agonist NAM	EC₅₀ < 200 mM^a	n/a	Schiffmann and Gimpl (2018)
H1R	Agonist NAM	EC₅₀ < 100 mM^a	3RZE	Hishinuma et al. (2017)
NTSR1	Agonist NAM	EC₅₀ = 43 mM	4BUO	White et al. (2018)
ET_A	Agonist NAM	EC₅₀ = 245 mM	n/a	Shihoya et al. (2017)

^{^a}

Approximately estimated from Na⁺ titration curves in the referenced papers.