TABLE 1.
Effects of antihypertensive drug classes on plasma vasoactive peptide levels and renin activity
| Drug Class | Ang I | Ang II | Ang 1-7 | BK 1-9 | ANP, BNP | PRC | PRA |
|---|---|---|---|---|---|---|---|
| ARB | ↑ | ↑↑ | ↑ | = | = | ↑↑ | ↑↑ |
| ACEi | ↑↑ | ↓ | ↑↑ | ↑ | = | ↑↑ | ↑↑ |
| C-ACEi | ↑↑ | ↓ | ↑ | = | = | ↑↑ | ↑↑ |
| NEPi | ↑ | ↑ | ↓ | ↑ | ↑ | = | = |
| ACEi/NEPi | ↑↑ | ↓ | ↑ | ↑↑ | ↑ | ↑↑ | ↑↑ |
| ARNI | ↑ | ↑↑ | = | ↑ | ↑ | ↑↑ | ↑↑ |
| AGT-siRNA | ↓↓ | ↓↓ | ↓↓ | = | = | ↑↑ | ↓↓ |
| DRI | ↓↓ | ↓↓ | ↓↓ | = | = | ↑↑ | ↓↓ |
| APAi | = | = | = | = | = | = | = |
| rhACE2 | ↑ | ↓↓ | ↑↑↑ | = | = | ↑↑ | ↑↑ |
Upward arrows indicate upregulation, downward arrows indicate downregulation, and equal signs indicate no change. ACEi, ACE inhibitor; ACEi/NEPi, dual ACE and NEP inhibitor; AGT-siRNA, angiotensinogen siRNA; APAi, amino peptidase A inhibitor; C-ACEi, C-domain–selective ACE inhibitor; DRI, direct renin inhibitor; NEPi, NEP inhibitor; PRA, plasma renin activity; PRC, plasma renin concentration.