Table 4.
Duration and Frequency of Behaviors in Juvenile Y-Maze Paradigm
| Average Group Duration |
Difference from Control Group |
||||||
|---|---|---|---|---|---|---|---|
| MIA1 Mean (SD) |
MIA2 Mean (SD) |
Control Group Mean (SD) |
MIA1 vs. Control Group |
MIA2 vs. Control Group |
|||
| Behavior | Estimate (SE) | p Value | Estimate (SE) | p Value | |||
| Startbox a | 19.7 (11.7) | 21.7 (12.2) | 17.1 (9.7) | 5.4 (5.9) | .37 | 5.8 (5.3) | .29 |
| Social Arm a | 51.1 (15.4) | 50.7 (10.4) | 48.5 (21.0) | 2.7 (9.7) | .78 | 2.3 (8.7) | .80 |
| Nonsocial Arm | 49.2 (19.7) | 47.6 (8.7) | 54.4 (24.5) | −8.1 (11.1) | .48 | −8.1 (10.0) | .43 |
| Average Group Frequency | Difference from Control Group | ||||||
| Coo Alone b,c | 2.3 (3.0) | 3.7 (2.9) | 4.9 (2.0) | −.8 (.4) | .06 | .6 (.4) | .14 |
| Coo to Novel c Animal2 | 2.1 (1.7) | 2.3 (1.4) | 3.0 (2.2) | −.2 (.4) | .53 | −.3 (.3) | .45 |
| Total Coob | 4.4 (4.5) | 6.0 (4.2) | 7.9 (3.3) | −2.3 (1.9) | .24 | −2.0 (1.8) | .28 |
| Stereotypies c | 2.5 (4.2) | 4.2 (2.9) | .7 (.6) | .6 (.4) | .14 | 1.3 (.4) | .002 |
Average group behaviors are based on observed duration or frequency of behaviors over 2-minute trials. Differences from control groups are estimated from mixed-effects regression models fitted to the duration or frequency of behaviors and adjusted for gender. Descriptive statistics and summary (parameter estimates and standard errors) of the mixed-effects models assessing the relationship between group and duration and frequency of behavioral variables.
MIA1, first trimester maternal immune activation; MIA2, second trimester maternal immune activation.
Analyses for these duration variables further adjusted for the day of the trial and gender of the stimulus monkey.
Analyses for these frequency variables further adjusted for the gender of the stimulus monkey.
Frequency variables square-root transformed to improve their normality.