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(A) Histogram of the patch sizes for intra- and inter- patches. While frequently mutated hub proteins have relatively large patches, most patches are small in size. (B) PTEN Patch 1—patch size—43 residues—an example of mutations forming a residue network from the surface to the core. (C) EGFR—three patches with different sizes: 11, 14 and 5 residues, respectively. (D) PIK3R1-PIK3CA—three inter-patches—each patch has at least one mutation in each partner protein.
