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. 2019 Jul 9;220(10):1589–1598. doi: 10.1093/infdis/jiz357

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© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Intravenous mouse infection model. Mice were passively immunized with the sera raised against DHG-PpiC (triangles) and DHG-SagA (squares) conjugates and challenged with Enterococcus faecalis type 2 and Enterococcus faecium 11236/1. After 48 hours of challenge, mice were euthanized, and their kidneys and livers were removed to assess viable counts. A and B, Viable counts in mice livers and kidneys challenged with E. faecalis type 2, respectively. C, Viable counts in mice livers challenged with E. faecium 11236/1. Each point represents the bacterial counts from a single mouse. Bars indicate the median number of colony-forming units (CFU) per gram of organ for the group. Statistical analysis was done by 1-way analysis of variance with the Dunnett post hoc test for comparison of the animals immunized with the antibodies raised against the DHG-protein conjugates to the control animals immunized with normal rabbit serum (NRS; circles). Horizontal bars represent geometric means. *P < .05, **P < .01, ***P < .001, and ****P < .0001.