Relative ability of several BAPTA derivatives to reduce or enhance synaptic transmission in young and aged slices, respectively. Values are mean ± SE. *p < 0.01; paired Student’s t test. Numbersin parentheses indicate the number of slices used.Kd, Estimated dissociation constant. The numbers of animals for each condition are as follows (young and old, respectively): BAPTA, four and five; EGTA, four and five; difluoro BAPTA, four and three; dibromo BAPTA, four and three; and dinitro BAPTA, six and four.