Fig. 2.
Modulation of the HVA channel currents by 5-HT and 5-HT agonists in cell-attached patches. A, Four consecutive recordings of HVA channel currents in a cell-attached patch. Bottom, Averaged trace from 30 consecutive recordings. The solid line is the best fit of a single exponential equation. B, Equivalent traces from the same patch after 5-HT was applied to the cell. C, Summary of the effects of 5-HT, 5-HT1A agonist 8-OH-DPAT, and 5-HT1D agonist L-694,247 on the HVA currents recorded in cell-attached patches. D, Summary of the effects of 5-HT on T-type currents recorded in the same batch of neurons.Inset, Representative traces of T-type currents (averaged from 20 consecutive recordings) recorded in the cell-attached patches in control, 5-HT, and after wash. n.s., Not significant; *p < 0.05, **p < 0.01 in this and all figures.