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Effect of rapamycin on the FK506- or cyclosporin A-mediated inhibition of APP increases in astrocytes treated with PGE2. Rapamycin (1 μm) antagonized the inhibitory effect of FK-506 (0.1 μm) but not of cyclosporin A (1 μm) on PGE2-mediated increases in APP holoprotein. Graph represents means and SEM from three independent experiments (*p < 0.05).
