Fig. 4.

Bath application of 50 μmmetrifonate to CA1 neurons from chronic metrifonate-treated subjects further significantly decreased the accommodation (B). This effect was significantly reversed by adding 1 μm atropine to the perfusate (C) (same neuron inA–C). The mean increase (with 50 μm metrifonate) and decrease (with 50 μmmetrifonate and 1 μm atropine) in the number of action potentials elicited in CA1 neurons from the chronic metrifonate-treated subjects are illustrated in D (mean ± SEM; **p < 0.01; paired t tests).