Table 2.

Biophysical properties of CA1 neurons from aging rabbits that have been chronically treated with either 12 mg/kg metrifonate or vehicle

	n	Postburst afterhyperpolarization			Accommodation (# of action potentials)	Input resistance (MΩ)
		Amplitude (mV)	Area (mVsec)	Duration (sec)
12 mg/kg metrifonate
aCSF	19	−4.38  ± 0.41	−3.87  ± 0.59	2.82  ± 0.35	8.76  ± 0.71	42.46  ± 2.57
Metrifonate (50 μm)	14	−3.80  ± 0.49	−3.18  ± 0.58	2.69  ± 0.42	10.75  ± 1.10	51.86  ± 2.33
Metrifonate (50 μm) + Atropine (1 μm)	15	−4.12  ± 0.47	−3.72  ± 0.61	3.31  ± 0.35	9.45  ± 0.91	43.13  ± 2.62
Vehicle
aCSF	28	−4.70  ± 0.34	−4.81  ± 0.70	3.16  ± 0.25	6.40  ± 0.40	44.94  ± 1.95
Metrifonate (50 μm)	17	−4.15  ± 0.47	−4.19  ± 0.88	3.31  ± 0.43	9.02  ± 0.93	47.53  ± 2.31
Metrifonate (50 μm) + Atropine (1 μm)	13	−4.78  ± 0.51	−5.25  ± 1.21	3.82  ± 0.42	7.37  ± 0.67	42.12  ± 4.26

The neurons were subjected to a bath application of metrifonate (50 μm) followed by metrifonate plus atropine (1 μm) after the initial baseline measurements were recorded. As mentioned in Materials and Methods, the neurons were given 10 min of rest/stabilization periods during each change of the bath perfusate. n indicates the number of cells recorded. The measurements are the mean ± SEM.