Table 3.

Mean change of biophysical properties of CA1 neurons from young and aging rabbits after bath application of carbachol, eserine, atropine, or aCSF in vitro

	n	Postburst afterhyperpolarization			Duration (sec)	Accommodation (# of action potentials)	Input resistance (MΩ)
		Amplitude (mV)	% AHP Δ	Area (mVsec)
Young
aCSF	13	−0.40  ± 0.35	−10.44  ± 4.93	−0.78  ± 0.79	0.37  ± 0.71	0.63  ± 0.40	1.28  ± 2.20
Atropine (1 μm)	5	0.11  ± 0.48	−1.89  ± 11.93	−0.14  ± 0.83	0.27  ± 0.28	1.25  ± 0.69	2.56  ± 7.05
Carbachol (500 nm)	11	−1.18  ± 0.30**	−29.25  ± 7.30	−1.74  ± 0.54**	−1.23  ± 0.69	4.74  ± 0.99***	3.45  ± 2.52
Eserine (500 nm)	7	−0.75  ± 0.45	−12.16  ± 11.53	−1.36  ± 0.64	−0.91  ± 0.39	2.11  ± 0.60**	2.41  ± 3.48
Eserine (1 μm)	14	−0.38  ± 0.12**	−16.38  ± 4.31	−0.51  ± 0.36	−0.50  ± 0.36	2.12  ± 0.48***	3.65  ± 1.30*
Eserine (5 μm)	7	−1.07  ± 0.33*	−27.62  ± 7.07	−1.83  ± 0.62*	−0.85  ± 0.40	4.81  ± 0.69***	−2.03  ± 2.38
Aging
aCSF	3	0.48  ± 0.35	14.87  ± 10.05	−0.58  ± 0.99	−1.52  ± 0.57	1.11  ± 0.78	−1.86  ± 0.92
Carbachol (500 nm)	14	−1.17  ± 0.27***	−22.74  ± 5.82	−2.30  ± 0.68**	−0.89  ± 0.38*	4.80  ± 0.90***	3.30  ± 2.27

n indicates the number of cells recorded. The numbers in bold type indicate statistical significance using pairedt test. The measurements are the mean ± SEM (*p < 0.05; **p < 0.01; ***p < 0.001; paired t tests).