Fig. 9.

Quantitative densitometry showed that COX activity in magnocellular terminals was significantly increased during the sprouting response in lesioned animals at 4 weeks (A, greater than 1 week intact or lesion, p < 0.02; marginally greater than 4 week intact, p < 0.07). In contrast, induction of CH abolished the lesion-induced increase in activity (B, less than 4 week lesion,p < 0.001) but had no effect in sham-lesioned controls. The proportional area of the NL with signal intensity above background was determined densitometrically after histochemical detection of COX activity in the neurosecretory terminal field (see Materials and Methods). Each point and error bar represent the mean and SEM of six to eight animals.