Fig. 1.

Changes in abdominal temperature (T_ab) after intracerebroventricular injection of LPS (closed circle) or saline (triangle). LPS (50 ng/rat) or saline (15 μl) was injected at time point 0, which was between 9:00 and 9:30 A.M. Each value represents the mean ± SE of four (saline) or five (LPS) rats. The change in T_ab was significantly different between LPS- and saline-injected rats in the time period denoted by theasterisk (p < 0.05). Their T_ab 1 d before the injection was also shown as the control (open circle).