Fig. 2.

Changes in T_ab of NS-398- or vehicle-pretreated rats after the intracerebroventricular injection of LPS. NS-398 (4 mg/kg; n = 4) or its vehicle (500 μl of 50% DMSO; n = 5) was injected intraperitoneally at time point 0. LPS (50 ng/rat) was injected via the intracerebroventricular route at the time point of 60 min. Each value represents the mean ± SE of four or five rats. The change in T_ab was significantly different between NS-398- and vehicle-pretreated rats in the time period denoted by theasterisk (p < 0.05).