Fig. 4.

Light microscopic views of localization of neuronal COX-2 mRNA signals in the untreated rats and saline- or LPS-injected ones. A–E were obtained from the layer II/III of the neocortex of injection side (except forA) in the plane of Figure2A1–E1. A, Constitutive COX-2 mRNA signals were observed in neuron-like cells (arrowheads). COX-2 mRNA signal was markedly enhanced in the neurons 1.5 hr after saline (B) or LPS (D) injection. The mRNA signals decreased until 3.5 hr after the injections (C, E). Scale bar (A–E), 20 μm.