Fig. 5.

Change in COX-2 mRNA level in the cortical areas. The optical densities of the autoradiographic films in each region were converted to the relative amount of radioactivity using a standard scale for ¹⁴C, the particles of which isotope possess almost the same energy as those of ³⁵S, allowing us to quantitate the relative amount of ³⁵S using the¹⁴C scale as the reference. The value in each region and time point was expressed as the ratio to that of untreated rats. The values for the neocortex (NC), including the cingulate/frontal cortex and the layers II-III of the neocortex, and piriform cortex (PC) were obtained in the plane of Figure 2A1–E1(n = 4). Significant differences from the untreated group (N) were denoted by *p < 0.05; significant differences between the injection side and the opposite side were denoted by #p < 0.05.