Fig. 6.

Light microscopic views of COX-2 mRNA signals in the blood vessels. A small amount of COX-2 mRNA (arrows) was induced in the cells of blood vessels near the lateral ventricles 1.5 (A) and 3.5 (C) hr after saline injection. Marked COX-2 mRNA signals were induced in blood vessels of the same area 1.5 (B) and 3.5 (D) hr after LSP injection. COX-2 mRNA (arrows) was also induced in blood vessels near the third ventricle 1.5 hr after LPS injection (E) and was further enhanced 3.5 hr after LPS injection (F,G). COX-2 mRNA was also induced in blood vessels of the subarachnoidal space (H).BV, Blood vessel; V3, third ventricle. Scale bars: A–D, G, 50 μm; E, F, 100 μm; H, 25 μm.