Fig. 3.
Effect of 5-HT1 agonists on stimulated CGRP release. 5-HT1 repression of CGRP release after stimulation by inflammatory agents. The amount of CGRP secreted per hour was normalized to the basal rate determined for 1 hr before addition of 60 mm KCl or 5-HT1 agonists. The relative rates after addition of buffer (CON), inflammatory cocktail (IFC), and IFC plus 10 μm sumatriptan (Suma), 10 μmCGS, or 10 μm L-694,247 (L694) are shown. The mean basal rate was 137 ± 2 pg/hr per dish. The means and the SE from at least three independent experiments are shown. *p < 0.001 when compared with control values.# p < 0.05 when compared with IFC values.