Table 3.
DA responses of spontaneously active striatal neurons after DA receptor blockade
| Parameters | Dopamine current (nA) | |||
|---|---|---|---|---|
| 5 | 10 | 20 | 40 | |
| SCH-23390 | ||||
| Number of units (tests) | 3 (5) | 16 (37) | 27 (81) | 12 (24) |
| Number of inhibitions (%) | 2 | 6 (16.2) | 15 (18.5) | 8 (33.3) |
| Number of excitations | 0 | 0 | 7 | 1 |
| F | 6.74* | 6.27* | 7.65* | |
| Mean changes in rate, % | 105.88 ± 20.29 | 94.17 ± 3.71 | 93.98 ± 5.87 | |
| Inhibition | ||||
| Range | 35.5–79.3 | 15.4–70.6 | 46.3–87.85 | |
| Relative magnitude | 56.82 ± 6.36 | 52.65 ± 4.19 | 70.32 ± 4.78 | |
| Eticlopride | ||||
| Number of units (tests) | 7 (16) | 15 (37) | 24 (74) | 7 (17) |
| Number of inhibitions (%) | 7 (43.8) | 23 (62.2) | 35 (47.3) | 8 (47.1) |
| Number of excitations | 0 | 1 | 3 | 0 |
| F | 18.05** | 50.32*** | 40.79*** | 7.39* |
| Mean changes in rate, % | 72.22 ± 6.11 | 60.22 ± 4.86 | 77.73 ± 4.73 | 69.98 ± 7.18 |
| Inhibition | ||||
| Range | 34.1–67.2 | 21.2–64.34 | 4.4–78.6 | 26.8–74.4 |
| Relative magnitude | 48.14 ± 5.12 | 43.97 ± 3.52 | 47.97 ± 3.10 | 50.47 ± 5.31 |
| SCH-23390 + Eticlopride | ||||
| Number of units (tests) | 3 (6) | 20 (68) | 12 (36) | 5 (7) |
| Number of inhibitions (%) | 3 (50.0) | 19 (27.9) | 4 (11.1) | 1 (14.3) |
| Number of excitations | 0 | 5 | 4 | 0 |
| n no responses | 3 | 44 | 28 | 6 |
| F | 4.16 | 9.05** | 0.41 | 1.33 |
| Mean changes in rate, % | 64.37 ± 11.71 | 98.08 ± 6.68 | 104.31 ± 6.21 | 97.33 ± 3.91 |
| Inhibition | ||||
| Range | 8.2–69.4 | 37.5–74.3 | ||
| Relative magnitude | 48.91 ± 4.29 | 59.77 ± 8.20 | ||
F values show the strength of the DA effect on impulse activity estimated by a one-way ANOVA with repeated measures. Asterisks indicate statistical significance of the effect (*p < 0.05; **p < 0.01; ***p < 0.0001). ± values refer to SEM.