Fig. 1.

Histological evidence for cannabinoid-mediated protection of CA1 hippocampal neurons in global cerebral ischemia. Rats underwent sham surgery or 15 min of cerebral ischemia induced by four-vessel occlusion, with or without the administration of drugs 40 min before the onset of ischemia. Animals were killed 3 d later and paraffin-embedded brain sections were stained with cresyl violet. Sections are shown at low (left, 25×) and high (right, 400×) power, after sham surgery (Sham) or after the induction of ischemia without (Isch) or with previous administration ofR(+)-WIN 55212-2 [R(+)],S(−)-WIN 55212-3 [S(−)], or SR 141716A (SR) at the indicated doses (milligrams per kilogram, i.p.). Asterisks at leftindicate the region within CA1 from which the fields shown atright were taken.