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. 1999 Apr 15;19(8):2887–2896. doi: 10.1523/JNEUROSCI.19-08-02887.1999

Fig. 4.

Fig. 4.

Most pyramidal cells do not respond to nicotinic agonist, but some show a small response. A, A recording from a pyramidal cell that was unresponsive to nicotinic agonist, representing the majority of pyramidal cells recording.A1, Membrane potential responses to depolarizing and hyperpolarizing current injections (300 pA).A2, The lack of effect of pressure application of 3 mm ACh (applied at the mark) on the membrane potential or the membrane current (A3; voltage clamp, VH = −70 mV) of the pyramidal cell. B, Recordings from a pyramidal cell showing a small response to nicotinic agonist, representing the minority of pyramidal cells. B1, Membrane response to depolarizing and hyperpolarizing current injection.B2, Response of membrane potential to pressure application of 3 mm ACh to the soma.B3, Response in membrane current to identical application of ACh. B4, This response was blocked by 10 nm MLA. Calibration: A, 10 mV, 100 pA, 200 msec, 500 msec; B1,2, 10 mV, 200 msec, 500 msec; B3,4, 20 pA, 500 msec.