Fig. 5.

Low concentrations of nicotine inhibit both the fast α7 nicotinic and the slow non-α7 nicotinic response.A₁, Reversible inhibition of the fast nicotinic current by bath-applied nicotine (5 μm).A₂, A plot of the peak fast inward currents (same cell as A₁) throughout the entire experiment showing the reversible inhibition by the varying concentrations of nicotine on the nicotinic currents.B₁, Reversible inhibition of the slow nicotinic currents by bath-applied nicotine (5 μm).B₂, A plot of the peak slow inward currents (same cell as B₁) throughout the experiment show the reversible inhibition of the slow nicotinic currents by concentrations of nicotine. C, Summary showing that 500 nm to 5 μm nicotine significantly inhibits both the slow and fast nicotinic current responses across all tested cells. Calibration: A, Vertical, 50 pA,horizontal, 500 msec; B,vertical, 40 pA, horizontal, 1 sec.