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. 1999 Jul 1;19(13):5586–5596. doi: 10.1523/JNEUROSCI.19-13-05586.1999

Fig. 7.

Fig. 7.

Cholinergic interneurons receive minimal spontaneous inhibitory synaptic input in vitro.A, In the presence of DNQX (40 μm) plus APV (50 μm) at a holding potential of −10 mV, a few small-amplitude outward currents are detectable. Application of 4-AP induced a large increase in the amplitude and frequency of spontaneous IPSCs, and their sensitivity to BMI (10 μm) indicates that they are mediated by GABAA receptors.B, Superimposed sweeps at a faster speed are shown to illustrate the kinetics of the 4-AP–induced IPSCs. C,D, The IPSCs are confirmed by their voltage-dependent reversal close to the chloride equilibrium potential to be caused by GABAA receptor activation.