Fig. 5.

Postsynaptic localization of Staufen protein and association with MTs and ERs. a, Staufen gold labeling (arrowheads) is exclusively found in dendrites (D) but not axonal terminals (AT) of hippocampal neurons (ratio of 13.4:1; see Results). Some gold clusters were associated with or in close vicinity of tubular ER structures in the dendritic process (38% of all gold; see Results). b, At higher magnification, mStau gold labeling is clearly seen in dendrites but not axonal terminals.c, Staufen labeling was found on bundles of MTs (mt) derived from a dendritic process. The nearby fasciculating axon above the dendrite did not contain any mStau label. Scale bar (in c): a, 250 nm;b, c, 200 nm. m, Mitochondria; sv, synaptic vesicle; t, tubular network; psd, postsynaptic density;mvb, multivesicular body.