Fig. 9.

The ADP-ribosyltransferase inhibitor nicotinamide suppresses LTP in the WT and cGK-deficient mice. Data from representative fEPSP recordings. Illustrated is the potentiation of the fEPSP slope in hippocampal slices from the WT (top, •), cGKI−/− (middle, •), and double-mutant (cGKI−/− cGKII−/−) (bottom, •) mice after a tetanus in the presence of nicotinamide (10 mm) (filled bars) and after wash-out. The cumulative potentiation of fEPSPs typically observed with repetitive tetanic stimulation in the control is superimposed for the WT (top, ○). Arrows indicate theta burst stimulation of the Schaffer collateral input.