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. 1999 Dec 1;19(23):10372–10382. doi: 10.1523/JNEUROSCI.19-23-10372.1999

Fig. 1.

Fig. 1.

Morphofunctional characteristics of a silent cell.A, This representative cell has just an anlage of apical dendrite and no basilar dendrite. In contrast, a long axon is observed in the stratum oriens (arrows). B, A 20 mV depolarizing step for 50 msec evoked a fast inward Na+ current that was blocked by bath application of TTX (1 μm) (the capacitive current has been truncated).C, Electrical stimulations (50–100 V, 30 μsec duration) of the stratum radiatum did not evoke synaptic currents at these three membrane potentials (mean of 10 traces evoked at 0.05 Hz). The truncated stimulation artifact is indicated by anarrow. D1, Current–voltage (I–V) relationship of AMPA receptor-mediated response. The insert shows the current generated by bath application of AMPA (5 μm, 1.5 min) at −70 mV. D2,I–V relationship of NMDA receptor-mediated response. The insert shows the current generated by bath application of NMDA (10 μm, 3 min) at −35 mV.D3, I–V relationship of isoguvacine-mediated response. The current generated by bath application of isoguvacine (10 μm, 1 min) at −70 mV is shown in the insert. or, Stratum oriens; py, stratum pyramidale; ra,stratum radiatum.